cees dekker Things To Know Before You Buy

cees dekker Things To Know Before You Buy

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Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules

Across the exact time, the team of Paul McEuen, who was then based within the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed using scanning tunnelling spectroscopy experiments.

Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters

Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design and style in 2005. (nl)

SMC complexes can move Bodily roadblocks bigger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion

We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which assess the elemental job of spatial confinement within the molecular and mobile stage. Our assignments incorporate the next:

Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

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Dekker started his investigate on solitary carbon nanotubes in 1993 when he set up a different line of analysis to check electrical transport through solitary organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was reached inside a collaboration While using the group of Nobel laureate Richard Smalley. STM and nanolithography procedures have been used to exhibit that these nanotubes are quantum wires at the single-molecule stage, with outstanding Bodily properties.

Due to the fact 2000 he moved to single-molecule biophysics and nanobiology, with investigate from reports of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Additional not too long ago his research has centered on researching chromatin construction and mobile division with microorganisms on chip, though he can be trying to in the long run Develop artificial cells from the bottom up.

Cees Dekker is Distinguished College Professor at TU Delft. Properly trained to be a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes in the nineteen nineties. Considering the fact that 2000, he moved to one-molecule biophysics and nanobiology. His latest exploration concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) building a dwelling artificial mobile from lifeless molecules. Dekker is surely an elected member in the KNAW cees dekker and fellow for the APS as well as the IOP.

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Illustration (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim of the pore is highlighted in red, plus a 3D rendering of your motion of your DNA rod is displayed.